Current issue
4 . 2023

In memory of Academician of the Russian Academy of Sciences Nikolay D. Yushchuk (December 22, 1940 – October 17, 2023)

Original researches

Long-term cytokine content in children with SARS-CoV-2-associated multisystem inflammatory syndrome in comparison with the initial period of the disease

Multisystem Inflammatory Syndrome in Children (MIS-C) is a quite rare condition linked to coronavirus disease (COVID-19). The issue related to the peculiarities of the pathogenesis of MIS-C has not been studied sufficiently and requires further research to identify risk

Features of cytokine status dynamics in patients with COVID-19 using Ambervin® Pulmo

The purpose of the study was to study cytokine-mediated effects in patients with coronavirus disease 2019 ( COVID-19) when using the drug Ambervin® Pulmo. Material and methods. The study included patients with moderate laboratory-confirmed COVID-19. Three groups were

Development of a reagent kit for the detection of SARS-CoV-2 virus RNA using real-time reverse transcription polymerase chain reaction

When lack of therapeutics for special prophylactic and current of new and existing viral infection the means development for early reveal and identification of agent has the priority significance. The aim of the work is to develop and test a set of reagents for detecting

Association between blood glucose levels and other comorbidities with outcomes of COVID-19 patients in a tertiary care hospital

Comorbidities increase the risk of severe COVID-19 and in turn higher mortality. There is a paucity of studies in South India that evaluated the presence of impaired blood glucose levels and other comorbidities as indicators of COVID-19 outcomes. Aim: to study the

Determination of total lactate dehydrogenase activity and the ratio of isotypes for predicting the severity of the course and diagnosis of organ lesions in COVID-19

Several studies have found that total lactate dehydrogenase (LDH) and its isotypes are associated with the severity of the course of coronavirus disease 2019 (COVID-19) and its outcomes. The aim of this work was to determine the significance of total LDH and its isotypes in

Course and outcomes of COVID-19 in hospitalized patients, considering the level of lymphopenia

The aim of the study is to identify the relationship between severity, outcomes of COVID-19 and lymphopenia in hospitalized patients. Material and methods. A retrospective study was conducted for 560 adult patients with a confirmed COVID-19 diagnosis of varying severity

The frequency of deaths from COVID-19 among vaccinated and unvaccinated individuals

The development of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccines and vaccination against coronavirus disease 2019 (COVID-19) for epidemic indications have contributed to a reduction in both morbidity and mortality. Fatal cases were recorded mainly in

Monitoring of antimicrobial resistance of uropathogenic strains of Escherichia coli

The problem of microbial resistance to antimicrobial drugs (AMD) has become a global issue; in many countries it is considered as one of the threats to national security. WHO has included Escherichia coli in the list of seven species of bacteria that cause life-threatening

Modern space-time features epidemic process of tick-borne viral encephalitis on the territory of the Tomsk region

The Tomsk Region belongs to the enzootic Russian Federation subjects in relation to natural focal zoonoses, including tick-borne viral encephalitis (TBVE). Work purpose – analysis of dynamics spatio-temporal features of the TBVE incidence in the Tomsk region. Material

Approach to immunoprophylaxis of infectious diseases in women during pregnancy and breastfeeding

The article provides evidence on the importance of immunoprophylaxis of infectious diseases in women during pregnancy and breastfeeding. Is shown, the positive effect of vaccination in this contingent of women on morbidity rates, severity of the course, deaths from

Evaluation of the inhaled immunosuppressants effectiveness in the treatment of COVID-19

A hyperimmune response to severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) often leads to severe uncontrolled inflammation in the lungs, complications and death. During the treatment of coronavirus disease 2019 (COVID-19), drugs from different pharmacological
Continuing medical education

Effectiveness of influenza vaccination in the context of the COVID-19 pandemic (material for preparing the lecture)

Influenza vaccination is an effective way to prevent infection with the influenza virus, the risk of severe clinical course and death, and to reduce the economic costs of the healthcare system for the treatment of patients. The purpose of the review was to evaluate the

The role of the student scientific circle in the formation of graduates of a new format – physicians researchers

In accordance with the development program of Sechenov University from 2021, the educational policy of the university is to train graduates of a new format – a doctor – researcher. The question of the role of the student scientific circle in the educational and
Practitioner’s consult

The debut of hereditary neurodegenerative disease on the background of addition of coronavirus infection

A description of a clinical case of the course of a coronavirus infection with a primary lesion of the central nervous system (cerebral edema and dementia) is presented. The peculiarity of this case is that the manifestation of clinical manifestations of a hereditary
Clinical tests

Klinikal cases (# 4, 2023)


Nikolay I. Briko (on the 70th anniversary of birth)


News (# 4, 2023)


All articles in our journal are distributed under the Creative Commons Attribution 4.0 International License (CC BY 4.0 license)

Aleksandr V. Gorelov
Academician of the Russian Academy of Sciences, MD, Head of Infection Diseases and Epidemiology Department of the Scientific and Educational Institute of Clinical Medicine named after N.A. Semashko ofRussian University of Medicine, Ministry of Health of the Russian Federation, Professor of the Department of Childhood Diseases, Clinical Institute of Children's Health named after N.F. Filatov, Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, Deputy Director for Research, Central Research Institute of Epidemiology, Rospotrebnadzor (Moscow, Russian Federation)

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