Current issue
2 . 2022
Content
Editorial

Dear readers!

Abstract
Editorial

Mechanisms of olfactory impairment in COVID-19: a systematic review

Abstract
One of the symptoms of a new coronavirus infection (COVID-19) is a complete or partial violation of the sense of smell. The aim of the work is to analyze the published results of scientific research on the mechanisms of olfactory impairment in COVID-19. Material and methods.
Original researches

Regulating vaccination: a comparative study

Abstract
Mandatory vaccination is seen as a landmark in public health. It has allowed all countries to effectively deal with several diseases such as small pox, polio. States usually follow a policy of mandatory vaccination in order to prevent the diseases from ever happening based

Clinical manifestations and emotional disorders in patients with new coronavirus infection (COVID-19)

Abstract
The Novel Coronavirus Disease (COVID-19) is characterized by a variety of clinical manifestations, including a predominant lesion of the respiratory system with the possible development of distress syndrome, the development of multiple organ failure. COVID-19 can cause

Clinical and immunological parallels in children patients with COVID-19

Abstract
The problem of the incidence of new coronavirus infection in childhood is becoming increasingly important. At the same time, questions arise regarding the peculiarities of the pathogenesis of COVID-19 in children. The aim of the research was to study the clinical and

Clinical and laboratory characteristics of new coronaviral infection (COVID-19) in children

Abstract
Another rise in the incidence of a new coronavirus infection (COVID-19), due to the penetration of the SARS-CoV-2 delta strain into Russia in the second half of April 2021, is characterized by rapid spread, severe course in adults and an increase in cases of the disease

Evaluation of clinical outcomes of COVID-19 in patients taking remdesivir in complex therapy in routine clinical practice

Abstract
Remdesivir (GS-5734) is a new direct-acting antiviral drug in the nucleotide analogue class with antiviral activity against SARS-CoV-2 and the ability to inhibit RNA-dependent RNA polymerase. Preliminary results from phase III randomized clinical trials of remdesivir are

Indicators of the functional state of the liver in infectious mononucleosis in adults

Abstract
Infectious mononucleosis (IM) caused by the Epstein-Barr virus (EBV) ranks sixth in terms of assessing the magnitude of economic damage from infectious diseases without tuberculosis and HIV in the Russian Federation. The polymorphism of clinical manifestations, the absence

Humoral and cellular immune responses in children 3–6 years old with infectious mononucleosis caused by primary and reactivation of Epstein–Barr viral infection

Abstract
In various sources there is not enough information about the features of immunological changes in children according to the critical periods of the development of the immune system. Infectious mononucleosis (IM) in primary Epstein–Barr virus infection (EBVI) with a

IL28B genetic polymorphism in chronic viral hepatitis

Abstract
As is known, parenteral viral hepatitis often occurs with the formation of cirrhosis of the liver. The exact mechanisms leading to the development of adverse outcomes of the disease are unknown. In recent years, the role of genetic determinants has been widely studied in the

Incidence of mixed cryoglobulinemia and its significance in the development of extrahepatic manifestations in chronic hepatitis C and co-infection chronic hepatitis C/HIV infection

Abstract
Cryoglobilinemia (CG) is pathological state that can be developed in patients with chronic infection caused by the hepatitis C virus (HCV) and also in patients co-infected with human immunodeficiency virus (HIV). Aim of the study was to investigate incidence of mixed CG and

Co-infection with Sindbis virus and West Nile virus in experiment

Abstract
Assessing the consequences of coinfection with various arboviruses requires understanding whether such infection leads to an increase in the severity of the disease. The aim was to study co-infection with Sindbis virus and West Nile virus in an experiment. Material and

Monitoring the composition of the intestinal microbiome in hematopoietic stem cell transplantation: application in clinical practice

Abstract
In this study, the composition of the intestinal microbiome in patients with hematopoietic stem cell transplantation was studied in real clinical practice. The published stage of the study included 12 adult patients who underwent allogeneic HSCT. The methods of graphical and
Reviews

Clinical and laboratory characteristics of new coronaviral infection (COVID-19) in children

Abstract
The review analyzed the problem of patients with kidney disease and approaches to vaccination of this group during the COVID-19 pandemic caused by the virus SARS-CoV-2. Patients with comorbid diseases are a vulnerable group for infection with a severe course and an

Pathogenetic relationship between the condition gut microbiota and liver diseases

Abstract
The human commensal microbiota is a collection of all microorganisms (viruses, bacteria, fungi) inhabiting different places of the human body. The composition of species, the ratio of potentially pathogenic strains and representatives of the normal human microbiota affect
Continuing medical education

Methodology of formation of an individual professional development trajectory of health care managers

Abstract
Increasing the demands of the population to ensure the availability and quality of medical care, the introduction of new methods of prevention, diagnosis and treatment of diseases, including on the basis of genetic technologies, the introduction of innovative management

National calendar of preventive vaccinations: present and future

Abstract
In the context of a pandemic of a new coronavirus infection, vaccine prophylaxis within the framework of the National Calendar of Preventive Vaccinations (NCPV) is an absolute priority in the fight against infectious diseases. The lecture presents the structure and features

Competency-based approach implementation in professional retraining of specialists for work with biological agents of I–II pathogenicity groups

Abstract
At present, the vector of educational paradigm has shifted towards changing the principles and requirements of state educational standards. Methodological basis for modernization in education, including continuing professional education, is a competency-based approach. In
Practitioner’s consult

Epidemic mumps on the background of reactivation of Epstein–Barr viral infection

Abstract
A clinical case of a combined course of Epstein–Barr viral infection and mumps in a 20-year-old man is presented. The combination of clinical symptoms characteristic of Epstein–Barr viral infection and hypersalivation, followed by an increase in α-amylase in
Clinical tests

Clinical case

Abstract
IN MEMORY OF RAKHIM M. KHAITOV

Rakhim M. Khaitov (01.06.1944–03.11.2022)

Abstract
News

News # 2, 2022

Abstract

All articles in our journal are distributed under the Creative Commons Attribution 4.0 International License (CC BY 4.0 license)

CHIEF EDITOR
Aleksandr V. Gorelov
Academician of the Russian Academy of Sciences, MD, Head of Infection Diseases and Epidemiology Department of the Scientific and Educational Institute of Clinical Medicine named after N.A. Semashko ofRussian University of Medicine, Ministry of Health of the Russian Federation, Professor of the Department of Childhood Diseases, Clinical Institute of Children's Health named after N.F. Filatov, Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, Deputy Director for Research, Central Research Institute of Epidemiology, Rospotrebnadzor (Moscow, Russian Federation)

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