Toxic myocarditis with a fatal outcome in a child with hemorrhagic fever with renal syndrome

Abstract

Hemorrhagic fever with renal syndrome (HFRS) is an acute viral zoonotic natural focal seasonal disease with different severity options. At the same time, the difficulty of diagnosing this infection is determined by the absence of specific clinical and morphological manifestations of the disease (especially in the early days). For laboratory confirmation of the diagnosis, the use of immunological and molecular biological methods is recommended. HFRS in children occurs rarely, in 3–5% of cases.

A clinical description of a case of HFRS in a 3-year-old child with a fatal outcome is presented, and the identified pathoanatomical picture is analyzed. The peculiarity of the clinical course of the disease was the absence of manifestations of the urinary syndrome in a child with HFRS, the mild skin hemorrhagic syndrome, and the most tanatogenetically significant was heart damage with a toxic myocarditis and cardiogenic shock.

Keywords:hemorrhagic fever with renal syndrome; toxic myocarditis; cardiogenic shock

Funding. The study was not sponsored.

Conflict of interest. The authors declare no conflicts of interests.

Contribution. The concept and design of the study – Avrelkina E.V., Anina A.N.; collection and processing of material, writing the text – Avrelkina E.V.; editing – Sergeev A.V.

For citation: Avrelkina E.V., Sergeev A.V., Anina A.N. Toxic myocarditis with a fatal outcome in a child with hemorrhagic fever with renal syndrome. Infektsionnye bolezni: novosti, mneniya, obuchenie [Infectious Diseases: News, Opinions, Training]. 2023; 12 (3): 146–52. DOI: https://doi.org/10.33029/2305-3496-2023-12-3-146-152 (in Russian)

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CHIEF EDITOR
Aleksandr V. Gorelov
Academician of the Russian Academy of Sciences, MD, Head of Infection Diseases and Epidemiology Department of the Scientific and Educational Institute of Clinical Medicine named after N.A. Semashko ofRussian University of Medicine, Ministry of Health of the Russian Federation, Professor of the Department of Childhood Diseases, Clinical Institute of Children's Health named after N.F. Filatov, Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, Deputy Director for Research, Central Research Institute of Epidemiology, Rospotrebnadzor (Moscow, Russian Federation)
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