The frequency and sensitivity to antimicrobial drugs of Staphylococcus aureus and Pseudomonas aeruginosa isolates from the lower respiratory tract in children with cystic fibrosis
AbstractA chronic lung infection is the leading cause of death for patients with cystic fibrosis. The article displays the data of a microbiological examination of children and adolescents with cystic fibrosis living in the Moscow region and the results of determining the antibiotic susceptibility of the main isolated pathogens.
The aim of the study was to research the spectrum of the microflora respiratory tract in children and adolescents with cystic fibrosis with the determination of the antibiotic sensitivity of the isolated strains of S. aureus and P. aeruginosa.
Material and methods. The study examined the discharge of the upper and lower respiratory tract in 127 (66.6%) pediatric patients with cystic fibrosis under the age of 18 using the bacteriological research method in the Moscow region.
Results. In children and adolescents with cystic fibrosis, S. аureus was isolated from the biological material of the upper and lower respiratory tract in 70.1% of cases, in 46.5% in monoculture and in 24% in association with other microorganisms. P. aeruginosa isolated in 23.6%, in monoculture 8.0%. In most cases, P. aeruginosa was associated with S. аureus. MRSA has been identified in 6.4% of children and adolescents with cystic fibrosis. The studied strains of S. aureus were 33% sensitive to benzylpenicillin, 25% to chloramphenicol and were resistant (75%) to ciprofloxacin. 56% of S. aureus strains remained sensitive to erythromycin. P. aeruginosa strains were resistant to ticarcillin/clavulanate), fluoroquinolones, third generation cephalosporins, imipenem, and aztreonam.
Conclusion. P. aeruginosa retains sensitivity to meropenem and aminoglycosides, and S. aureus to tigecycline, teicoplanin, vancomycin, linezolid, fosfomycin, and fusidic acid. Monitoring the antibiotic susceptibility of microorganisms isolated from patients with cystic fibrosis allows to optimize the tactics of antimicrobial therapy, considering the update from European Committee on Antimicrobial Susceptibility Testing (EUCAST).
Keywords:cystic fibrosis; antibiotic resistance; children and adolescents
Funding. The study was not sponsored.
Conflict of interest. The authors declare no conflict of interest.
Contribution. The concept and design of the study – Akimkin V.G., Kondratyeva E.I., Ploskireva A.A.; collection of clinical material and sputum sampling – Voronkova A.Yu., Kondratyeva E.I., Fatkhullina I.R.; microbiological research – Tronza T.V., Tivanova E.V., Fedotova N.Ya.; statistical processing – Tronza T.V.; writing the text – Kondratyeva E.I., Tronza T.V., Fatkhullina I.R., Voronkova A.Yu.; editing – Kondratyeva E.I., Gorelov A.V., Akimkin V.G., Ploskireva A.A.
For citation: Tronza T.V., Voronkova A.Yu., Fedotova N.Ya., Fatkhullina I.R., Tivanova E.V., Ploskireva A.A., Gorelov A.V., Kondratyeva E.I., Akimkin V.G. The frequency and sensitivity to antimicrobial drugs of Staphylococcus aureus and Pseudomonas aeruginosa isolates from the lower respiratory tract in children with cystic fibrosis. Infektsionnye bolezni: novosti, mneniya, obuchenie [Infectious Diseases: News, Opinions, Training]. 2023; 12 (1): 62–8. DOI: https://doi.org/10.33029/2305-3496-2023-12-1-62-68 (in Russian)
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