Prophylactic measures efficiency evaluation in preventing tick-borne encephalitis infection

Abstract

The aim of the study was to evaluate the effectiveness of preventive measures aimed at tick-borne encephalitis virus infection prevention.

Material and methods. The data analysis of federal statistical observation forms No. 1, 2, 5 was carried out. The data from vaccination points of Tomsk region and the cards of epidemiological investigation of cases of tick-borne encephalitis infection for the period 2009–2021 were considered. The efficacy of different types of prophylaxis was evaluated quantitatively based on odds ratio (OR) calculation.

Results and discussion. Evaluation of the effectiveness of preventive measures aimed at preventing tick-borne encephalitis virus infection showed that the odds of developing the disease were lower in people vaccinated against tick-borne encephalitis [OR 0.385, 95% confidence interval (CI) 0.306; 0.486] or who used Iodantinopyrin® (OR 0.162, 95% CI 0.101; 0.262). It was found that among vaccinated patients with tick-borne encephalitis the disease had a milder course, as well as among those who received emergency prophylaxis with human immunoglobulin against tick-borne encephalitis. The use of Iodantipyrin® prevented the development of meningoencephalitic forms of tick-borne encephalitis.

Keywords:tick-borne encephalitis; vaccine prophylaxis; Iodantipyrin®; human immunoglobulin against tick-borne encephalitis; emergency prophylaxis

Funding. The study had no sponsor support.

Conflict of interest. The authors declare no conflict of interests.

Contribution. The concept and design of the study – Poltoratskaya T.N., Zhukova N.G.; collection and processing of the material – Poltoratskaya N.V., Pankina T.M., Adaev E.A.; statistical processing – Poltoratskaya N.V., Sunchugasheva K.N.; writing of the text – Poltoratskaya T.N., Poltoratskaya N.V.; editing by Shikhin A.V.

For citation: Poltoratskaya N.V., Poltoratskaya T.N., Zhukova N.G., Adaev E.A., Shikhin A.V., Pankina T.M., Sunchugasheva K.N. Prophylactic measures efficiency evaluation in preventing tick-borne encephalitis infection. Infektsionnye bolezni: novosti, mneniya, obuchenie [Infectious Diseases: News, Opinions, Training]. 2023; 12 (1): 40–6. DOI: https://doi.org/10.33029/2305-3496-2023-12-1-40-46 (in Russian)

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CHIEF EDITOR
Aleksandr V. Gorelov
Academician of the Russian Academy of Sciences, MD, Head of Infection Diseases and Epidemiology Department of the Scientific and Educational Institute of Clinical Medicine named after N.A. Semashko ofRussian University of Medicine, Ministry of Health of the Russian Federation, Professor of the Department of Childhood Diseases, Clinical Institute of Children's Health named after N.F. Filatov, Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, Deputy Director for Research, Central Research Institute of Epidemiology, Rospotrebnadzor (Moscow, Russian Federation)

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