Infectious mononucleosis combined with SARS-CoV-2 infection

Abstract

A clinical analysis of COVID-19 cases combined with acute respiratory diseases is presented.

The aim of the study was to analyze clinical and laboratory data of patients with combined COVID–19 infection.

In patient A. infected with SARS-CoV-2 without X-ray confirmation of lung damage, acute tonsillitis, polyadenopathy, hepatosplenomegaly, moderate leukocytosis, lymphomonocytosis and the presence of reactive lymphocytes were detected. Serological and molecular biological studies were carried out for the purpose of differential diagnosis. A positive test result for IgM antibodies to EBV was obtained. The method of polymerase chain reaction (PCR) revealed EBV DNA in blood plasma. The result of the determination of heterogeneous IgG antibodies to the EBV caspid antigen is negative.

Clinical symptoms of the patient with coronavirus infection COVID-19, confirmed by radiological and serological screening, included: fever, sore throat, hyperemia and hypertrophy of the palatine tonsils, hepatomegaly, changes of the cellular composition of the blood. At the same time, the lymph nodes in the neck, chest and abdominal cavity were not enlarged; the presence of reactive lymphocytes and plasma cells was not detected. Serological markers of EBV were also not detected. A PCR test for Epstein–Barr virus DNA was negative.

Keywords:infectious mononucleosis; Epstein–Barr virus; COVID-19; tonsillitis; SARS-CoV-2 coronavirus

Funding. The study had no sponsor support.

Conflict of interest. The authors declare no conflict of interest.

Contribution. Research concept, paper design, text writing and editing – Kalenchic T.I., Kabak S.L.; material collection and processing – Rysevets A.U.

For citation: Kalenchic T.I., Kabak S.L., Rysevets A.U. Infectious mononucleosis combined with SARS-CoV-2 infection. Infektsionnye bolezni: novosti, mneniya, obuchenie [Infectious Diseases: News, Opinions, Training]. 2022; 11 (4): 134–8. DOI: https://doi.org/10.33029/2305-3496-2022-11-4-134-138

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CHIEF EDITOR
Aleksandr V. Gorelov
Academician of the Russian Academy of Sciences, MD, Head of Infection Diseases and Epidemiology Department of the Scientific and Educational Institute of Clinical Medicine named after N.A. Semashko ofRussian University of Medicine, Ministry of Health of the Russian Federation, Professor of the Department of Childhood Diseases, Clinical Institute of Children's Health named after N.F. Filatov, Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, Deputy Director for Research, Central Research Institute of Epidemiology, Rospotrebnadzor (Moscow, Russian Federation)

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