Effectiveness of regional varicella vaccination programmes

Abstract

The article presents data on the epidemic process of varicella (chickenpox) in Moscow and the Sverdlovsk region against the background of many years of use of varicella vaccines in the implementation of regional programs for children’s immunization against varicella. An estimate of the volume of varicella vaccination in these regions is given.

Aim. Evaluation of the effectiveness of varicella vaccination within the framework of regional vaccination schedules in Moscow and the Sverdlovsk region for the scientific substantiation of recommendations for expanding the National Immunization Schedule of the Russian Federation.

Material and methods. To assess the epidemic situation in terms of the incidence of varicella in 2006–2021, data from forms No. 2 of the Federal State Statistical Observation “Information on infectious and parasitic diseases” and forms No. 23-17 “Information on outbreaks of infectious diseases” in Moscow in 2017–2021 were used. To assess the volume of vaccination against chickenpox, we took into account the data of form No. 5 of the Federal State Statistical Observation “Information on preventive vaccinations” in the Russian Federation and certain territories in 2013–2021. We have carried out a retrospective epidemiological analysis of the distribution of the incidence of chickenpox in general on the territory of the Russian Federation, Moscow and the Sverdlovsk region.

Results and discussion. In the regions of the Russia where the planned varicella vaccination of children is carried out with low coverage and the use of a single-dose immunization scheme, after the success of regional programs in the first years of their implementation, the “growing up” of infection, an increase in the incidence of varicella of children of the first year of life, and an increase in the probability of congenital forms were revealed. Against the background of a decrease in the incidence of varicella in 2020–2021, as a result of restrictive measures in organized groups, as part of the response to the COVID-19 epidemic, susceptible individuals accumulate, which allows predicting another epidemic increase in incidence.

Conclusion. Based on regional experience, it is recommended to introduce 2 doses of varicella vaccination into the National Vaccination Schedule with at least 90% coverage.

Keywords:chickenpox; morbidity; vaccinoprophylaxis; regional immunization programs; national vaccination schedule

Funding. The study had no sponsor support.

Conflict of interest. The authors declare no conflict of interest.

Contribution. Research concept and design, editing – Mikheeva I.V.; collection and processing of material, statistical processing, writing text – Afonina N.M.

For citation: Afonina N.M., Mikheeva I.V. Effectiveness of regional varicella vaccination programmes. Infektsionnye bolezni: novosti, mneniya, obuchenie [Infectious Diseases: News, Opinions, Training]. 2022; 11 (3): 95–103. DOI: https://doi.org/10.33029/2305-3496-2022-11-3-95-103

References

1. On the state of sanitary and epidemiological well-being of the population in the Russian Federation in 2019: State report. Moscow: Federal’naya sluzhba po nadzoru v sfere zashchity prav potrebiteley i blagopoluchiya cheloveka, 2020: 299 p. URL: https://www.rospotrebnadzor.ru/documents/details.php?ELEMENT_ID=14933 (in Russian)

2. Kaira A.N., Lavro V.F., Svitich O.A., et al. Features of the epidemiology of chickenpox in a single territory. Epidemiologiya i vaktsinoprofilaktika [Epidemiology and Vaccine Prophylaxis]. 2020; 19 (2): 63–9. DOI: https://doi.org/10.31631/2073-3046-2020-19-2-63-69 (in Russian)

3. Afonina N.M., Mikheeva I.V. Modern epidemiological characteristics of chickenpox in Russia. One Health & Risk Management. 2020; (1): 12–21. DOI: https://doi.org/10.5281/zenodo.3700955 (in Russian)

4. Voronin E.M., Ermolenko M.V., Chernova A.M., et al. Modern features of the epidemic process of chickenpox. Epidemiologiya i vaktsinoprofilaktika [Epidemiology and Vaccine Prophylaxis]. 2010; 6 (55): 17–23 (in Russian)

5. Epidemiology and Prevention of Vaccine-Preventable Diseases. 2017. URL: https://www.cdc.gov/vaccines/pubs/pinkbook/index.html

6. Mikheeva I.V., Voronin E.V., Ermolenko M.V., et al. Planned vaccinal prevention of chickenpox: tactics and prospects. Epidemiologiya i infektsionnye bolezni. Aktual’nye voprosy [Epidemiology and Infectious Diseases. Actual Issues]. 2011; (2): 42–8. (in Russian)

7. Namazova-Baranova L.S., Fedoseenko M.V., Baranov A.A. New horizons of national immunization calendar. Voprosy sovremennoy pediatrii [Problems of Modern Pediatrics]. 2019; 18 (1): 13–30. DOI: https://doi.org/10.15690/vsp.v18i1.1988

(in Russian)

8. Mikheeva M.A., Mikheeva I.V. Dynamics of the rating of economic damage from infectious diseases as a criterion for the effectiveness of epidemiological control. Zhurnal mikrobiologii, epidemiologii i immunobiologii [Journal of Microbiology, Epidemiology and Immunobiology]. 2020; 97 (2): 174–81. DOI: https://doi:10.36233/0372-9311-2020-97-2-174-181 (in Russian)

9. Filippov O.V., Bol’shakova L.N., Elagina T.N. Regional calendar of preventive vaccinations in Moscow: history, development, prospects. Epidemiologiya i vaktsinoprofilaktika [Epidemiology and Vaccine Prophylaxis]. 2020; 19 (4): 63–75. DOI: https://doi.org/10.31631/2073-3046-2020-19-4-63-75 (in Russian)

10. Yakovleva T.V., Akimkin V.G., Lytkina I.N. Prospects for the development of the National calendar of preventive vaccinations. Epidemiologiya i vaktsinoprofilaktika [Epidemiology and Vaccine Prophylaxis]. 2011; 1 (56): 44–50. (in Russian)

11. Shamsheva O.V. Regional vaccination schedules as a step towards improving preventive work in Russia. Experience of foreign countries. Detskie infektsii [Children’s Infections]. 2010; (4): 4–9. (in Russian)

12. Kovtun O.P., Romanenko V.V., Kazakevich N.V., et al. Regional vaccine prevention program: ways of creation, achievements and prospects. Pediatricheskaya farmakologiya [Pediatric Pharmacology]. 2010; 7 (4): 19–24. (in Russian)

13. Experience of vaccinal prevention of chicken pox in Yekaterinburg. Pediatricheskaya farmakologiya [Pediatric Pharmacology]. 2010; 7 (4): 34–7. URL: https://cyberleninka.ru/article/n/opyt-provedeniya-vaktsinoprofilaktiki-vetryanoy-ospy-v-g-ekaterinburge (in Russian)

14. Sverdlovsk region is freed from chickenpox. Regnum. 2011. URL: https://regnum.ru/news/1472087.html (in Russian)

15. Varicella and herpes zoster vaccine: WHO position paper. WHO Weekly Epidemiological Bulletin 20 June 2014. WHO, 2014. URL: https://www.who.int/immunization/position_papers/varicella_herpes_zoster_vaccine_pp_ru_2014.pdf

16. Afonina N.M. Epidemiological characteristics and measures to prevent infection caused by the Varicella zoster virus: Diss. Moscow, 2019: 175 p. URL: https://rusneb.ru/catalog/000199_000009_008702916/ (in Russian)

17. Asano Y. Varicella vaccine: the Japanese experience. J Infect Dis. 1996; 174 (3): 310–3.

18. Chaves S.S., Gargiullo P., Zhang J.X., et al. Loss of vaccine-induced immunity to varicella over time. N Engl J Med. 2007; 356: 1121–9. DOI: https://doi.org/10.1056/NEJMoa064040

19. Marin M., Guris D., Chaves S.S., et al. Prevention of varicella: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2007; 56: 1–40.

CHIEF EDITOR
CHIEF EDITOR
Yushchuk Nikolay Dmitrievich
Academician of the Russian Academy of Sciences, Professor, head of the Infectious Diseases and Epidemiology Department, President of the Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Board member of the National Scientific Infectiologists? Society.
Вскрытие
Medicine today

Приветствуем вас в новом 2023 году, который мы встретили с надеждой и неизменно с планами на будущее! Традиционно в феврале ученики Николая Олеговича Миланова, сотрудники основанной им кафедры в Сеченовском Университете, планируют проведение уже девятой мемориальной...

Уважаемые коллеги! 10.02.2023 состоится Совместный научно-образовательный симпозиум Национальной Ассоциации по тромбозу и гемостазу и ФГБНУ "Научный центр неврологии" "Тромботические проблемы при цереброваскулярной патологии и коморбидных процессах". Начало регистрации в...

Приглашаем специалистов Сибирского федерального округа 9-10 февраля посетить Школу РОАГ! Успешно продолжается образовательная работа общероссийского проекта "Школы РОАГ". Очередная встреча пройдет 9-10 февраля в онлайн-формате и объединит врачей Иркутска, Кемерово, а также...


Journals of «GEOTAR-Media»