Some clinical and epidemiological aspects of the course of COVID-19 in people living with HIV

Abstract

Objective. To describe the clinical and epidemical characteristics of a new coronavirus disease 2019 (COVID-19) in people living with HIV, for HIV infection implies the development of an immunosuppressive condition that may exacerbate the course of COVID-19.

Material and methods. The research is based on retrospective and current epidemiological situation of HIV and SARS-CoV-2 infections in the Southern Russia regions during 2020 and survey of the patients with the co-infections concerning epidemiological, clinical, and laboratory diagnostic information. We collected all data from 15 regional centers for AIDS prevention and control in the Southern and North Caucasus Federal Districts. The survey sample consists of 121 patients. Statistical computation is done with Microsoft Office Excel 2010.

Results and discussion. HIV patients of various age and social characteristics are involved in the COVID-19 epidemic process. Within registered HIV and SARS-CoV-2 co-infections all patients have apparent clinical symptoms. Asymptomatic cases are not presented. Mild cases prevail in the sample (48.8%). The frequency of severe and extremely severe was significantly higher in people living with HIV/AIDS on ART more than 2 months against naive PLHIV or using ART up two one month (р<0.05).

Keywords:HIV infection; COVID-19; epidemic situation; clinical course; people living with HIV/AIDS; antiretroviral therapy

Funding. The study has no sponsor support.

Conflict of interest. The authors declare no conflict of interest.

Contribution. Research design, obtaining and analysis of the data, writing the text of the manuscript – Dolgova N.N., Ryndich A.A., Suladze A.G., Matuzkova A.N.; writing the text of the manuscript, review of publications on the topic – Tverdokhlebova T.I., Bolatchiev K.Kh., Chernigovec L.F.

For citation: Dolgova N.N., Ryndich A.A., Suladze A.G., Tverdokhlebova T.I., Matuzkova A.N., Bolatchiev K.Kh., Chernigovec L.F. Some clinical and epidemiological aspects of the course of COVID-19 in people living with HIV. Infektsionnye bolezni: novosti, mneniya, obuchenie [Infectious Diseases: News, Opinions, Training]. 2022; 11 (1): 41–6. DOI: https://doi.org/10.33029/2305-3496-2022-11-1-41-46

References

1.Pokrovsky V.V. Coronavirus against human immunodeficiency virus: predator vs. alien. Èpidemiologiâ i infekcionnye bolezni. Aktual’nye voprosy [Epidemiology and Infectious Diseases. Current Items]. 2020; 10 (3): 7–16. DOI: https://dx.doi.org/10.18565/epidem.2020.10.3.7-16 (in Russian)

2. BHIVA, DAIG, EACS, GESIDA & Polish Scientific AIDS Society Statement on risk of COVID-19 for people living with HIV (PLWH)

3. Blanco J.L., Ambrosioni J., Garcia F., Martínez E., et al. COVID-19 in patients with HIV: clinical case series. Lancet HIV. 2020; 7 (5): e314-6. DOI: https://doi.org/10.1016/S2352-3018(20)30111-9

4. Guo W., Ming F., Dong Y. et al. A survey for COVID-19 among HIV/AIDS patients in two districts of Wuhan, China. Preprint research paper, The Lancet, 2020.

5. Tverdokhlebova T.I., Kovalev E.V., Karpushchenko G.V., Litovko A.R., et al. Some epidemiological aspects of the new coronavirus infection (COVID-19) in Rostov region. Infekcionnye bolezni [Infectious Deseases]. 2020; 18(3): 21–9. DOI: https://doi.org/10.20953/1729-9225-2020-3-21-29 (in Russian)

All articles in our journal are distributed under the Creative Commons Attribution 4.0 International License (CC BY 4.0 license)

CHIEF EDITOR
Aleksandr V. Gorelov
Academician of the Russian Academy of Sciences, MD, Head of Infection Diseases and Epidemiology Department of the Scientific and Educational Institute of Clinical Medicine named after N.A. Semashko ofRussian University of Medicine, Ministry of Health of the Russian Federation, Professor of the Department of Childhood Diseases, Clinical Institute of Children's Health named after N.F. Filatov, Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, Deputy Director for Research, Central Research Institute of Epidemiology, Rospotrebnadzor (Moscow, Russian Federation)

Journals of «GEOTAR-Media»