Levels of plasma soluble CD14 in HIV-positive patients during opioid withdrawal syndrome

• Anastasiya N. Kholodnaya
• Vladimir Ya. Palatkin
• Marina V. Vetrova
• Elena A. Blokhina
• Tatyana S. Yaroslavtseva
• Evgeny M. Krupitskiy
• Dmitry A. Lioznov

Abstract

Opioid use in HIV-positive patients is a risk factor of the fast HIV-disease progression and worse health outcomes. There is a limited data about opioid influence on the endotoxin-induced immune activation in HIV-infected people, especially during withdrawal syndrome. Soluble receptor CD14 - biomarker of endotoxin-induced monocyte activation which in previous studies shown prognostic significance in the terms of HIV-disease outcomes.

The aim: to assess sCD14 concentration in blood plasma as a marker of the endotoxin induced monocyte activation in HIV-positive people during opioid withdrawal as well as with active opioid use.

Material and methods. A cross-sectional study of 211 HIV positive ART-naive participants was conducted. Plasma sCD14 concentration was evaluated once in groups of patients who undergo the peak of withdrawal (n=53), those who reported recent (past 30 days) opioid use (n=115) and in 43 participants without lifetime opioid use.

Results. The plasma sCD14 level was significantly lower in HIV-positive patients who undergo opioid withdrawal syndrome compare to those who reported recent opioid use [mean difference (95% CI) = 50.7 ng/ml (612.8-1007.2), p<0.0001] and compare to subjects without lifetime opioid use [mean difference (95% CI) = -23.8 ng/ml (-327.7... -730), p<0.0001].

Conclusion. There are lower endotoxin-induced immune response in HIV-positive patients during opioid withdrawal treatment.

Keywords:HIV, sCD14, monocyte activation, PWID, opioid, opioid withdrawal syndrome

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