Features of seroprevalence to Coxiella burnetii in patients with brucellosis living in an enzootic territory

• Dmitry G. Ponomarenko
• Ol'ga V. Logvinenko
• Ekaterina L. Rakitina
• Marina V. Kostyuchenko
• Dar'ya E. Lukashevich
• Кotenev Е.S.
• Volynkina Anna S.
• Anna A. Khachaturova
• Anastasiya N. Germanova
• Nushik S. Sarkisyan
• Nadezhda I. Kovalevich
• Irina Yu. Borzdova
• Ol'ga G. Golub'
• Kulichenko A.N.

Abstract

The results of studying the characteristics the state of seroprevalence to antigens Brucella spp. and Coxiella burnetii in patients with brucellosis living on enzootic territory (Stavropol territory). In overwhelming majority (71.5%) of patients with acute brucellosis in the compensation phase, simultaneous presence of specific IgM + IgG + IgA was revealed. In addition, among patients with a confirmed diagnosis of acute brucellosis, the proportion of persons with IgM and IgG to antigens phase II C. burnetii accounted for 32.6%. Persons with chronic brucellosis infection showed persistence mainly combinations of specific IgG + IgA, IgM + IgG + IgA and much less often one class of immunoglobulins G or A. In 47.5% of those examined with a confirmed diagnosis of chronic brucellosis, were identified specific IgG to antigens to phase I C. burnetii. The conducted studies confirm the possibility of coinfection with the pathogens of brucellosis and Q fever. The detection of immunological markers brucellosis and Q fever in residents of Stavropol territory can be fairly objectively regarded as an indicator the presence of active combined epizootic foci of these infections with the potential to provide epidemic manifestations in this territory.

Keywords:seroprevalence, brucellosis, Q fever, co-infection, enzootic territory

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