Immunopathogenetic options of Epstein-Barr virus infection

Abstract

The aim of the study was to identify the features of the humoral virus - specific immune response in various variants of the course of Epstein-Barr virus infection.

Material and methods. Laboratory examination of 99 adult patients was performed using immunoblotting for semi-quantitative determination of specific IgG and IgM antibodies to EBV proteins.

Results. 81.2% of patients showed signs of immune system response to EBV. The features of the immune response to Epstein-Barr virus proteins in primary and chronic infection were established. The information content of antibody patterns to various virus proteins was determined.

Conclusion. An in-depth study of the immunopathogenesis of Epstein-Barr virus infection, in particular, the assessment of the profile of virus-specific antibodies, allows us to determine the stage of infection and justify the need for etiotropic therapy.

Keywords:Epstein-Barr virus infection, adults, chronic infection, antibody patterns

Funding. The study had no sponsor support.

Conflict of interests. The authors declare no conflict of interests.

Contribution. Research concept and design, text writing, editing - Valishin D.A.; material collection and processing, statistical processing, text writing, editing - Suzdaltseva N.A.

For citation: Suzdaltseva N.A., Valishin D.A. Immunopathogenetic options of Epstein-Barr virus infection. Infektsionnye bolezni: no-vosti, mneniya, obuchenie [Infectious Diseases: News, Opinions, Training]. 2020; 9 (4): 88-91. DOI: https://doi.org/10.33029/2305-3496-2020-9-4-88-91 (in Russian)

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CHIEF EDITOR
Aleksandr V. Gorelov
Academician of the Russian Academy of Sciences, MD, Head of Infection Diseases and Epidemiology Department of the Scientific and Educational Institute of Clinical Medicine named after N.A. Semashko ofRussian University of Medicine, Ministry of Health of the Russian Federation, Professor of the Department of Childhood Diseases, Clinical Institute of Children's Health named after N.F. Filatov, Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, Deputy Director for Research, Central Research Institute of Epidemiology, Rospotrebnadzor (Moscow, Russian Federation)

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