Features of the steroid profile of saliva in patients with COVID-19

Abstract

Material and methods. The study included 16 men aged 28 to 81 years (average age 50.3+13.4 years) with confirmed new coronavirus infection of varying severity, were hospitalized in April 2020 in Moscow COVID hospital. Patients were divided into three groups, depending on the severity of COVID-19: the 1st group was a mild course (n=7), the 2nd group was a moderate course (n=7), and the 3rd group was a severe course of the disease (n=2). All patients were cured.

In addition to the steroid profile of saliva, all patients underwent a test for arbitrary breath holding (Stange test), which reflects the reserve capabilities of the lungs, as well as a general blood test. In 6 patients, vitamin D was determined by mass spectrometry.

Results and discussion. There was a testosterone deficiency in all patients with COVID-19, while there was a connection between a decrease in testosterone and the severity of the disease: the maximum decrease in testosterone was observed in patients with severe disease.

Conclusion. Given the known effect of testosterone on the synthesis of nitric oxide, a deficiency of which leads to the development of not only insulin resistance and oxidative stress, chronic hypoxia, but also bronchospasm and pulmonary edema, it is necessary to include the determination of the steroid profile of saliva in the diagnostic algorithms for managing patients with a new coronavirus infection COVID-19.

Keywords:COVID-19, steroid profile of saliva, testosterone, sex hormones, hypoxia, vitamin D, nitric oxide

Funding. The study did not have sponsorship.

Conflict of interest. Authors declare no conflict of interest.

Contribution. Kalinchenko S.Yu. - editing and writing an article; Ivanov S.Yu. - collection, analysis and processing of patient data, editing and writing an article; Borozdkin L.L. - collection, analysis and processing of patient data; Shurmudov A.R. - collection, analysis and processing of patient data; Terushkin R.A. - collection and analysis of data, editing and writing an article; Isaev A.N. -conducting, and processing analyzes; Avetisyan A.R. - data analysis and processing, article editing.

For citation: Kalinchenko S.Yu., Ivanov S.Yu., Borozdkin L.L., Shurmudov A.R., Terushkin R.A., Isaev A.N., Avetisyan A.R. Features of the steroid profile of saliva in patients with COVID-19. Infektsionnye bolezni: novosti, mneniya, obuchenie [Infectious Diseases: News, Opinions, Training]. 2020; 9 (4): 54-9. DOI: https://doi.org/10.33029/2305-3496-2020-9-4-54-59 (in Russian)

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CHIEF EDITOR
Aleksandr V. Gorelov
Academician of the Russian Academy of Sciences, MD, Head of Infection Diseases and Epidemiology Department of the Scientific and Educational Institute of Clinical Medicine named after N.A. Semashko ofRussian University of Medicine, Ministry of Health of the Russian Federation, Professor of the Department of Childhood Diseases, Clinical Institute of Children's Health named after N.F. Filatov, Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, Deputy Director for Research, Central Research Institute of Epidemiology, Rospotrebnadzor (Moscow, Russian Federation)

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