Changes in the level of cytokines in the serum of children blood with hemorrhagic fever with renal syndrome

• Guzel M. Khasanova
• Tutelyan Aleksey V.
• Damir A. Valishin
• Svirina Anastasiya S.
• Khasanova Aliya N.
• Mukhetdinova Guzel A.

Abstract

The article analyzes the level of serum cytokines in children with HFRS. The study was conducted in 47 children of them in 25 of whom had HFRS medium-severe form, in 22 - HFRS of severe form. The age of those examined in these two groups was 5-17 years. The mean age in the 1^st group was 11.1±1.6 years, in the 2^nd group - 11.3±1.3 years. To compare the cytokine status, 24 healthy children aged 5 to 17 years were examined for the cytokine status, the mean age of the control group was 11.2±1.4 years. The content of cytokines IL-1β TNFα INFα INF-γ IL-10 in patients was studied in febrile, oliguric, polyuric periods and in the period of convalescence, 1 month after discharge from the hospital. The cytokine content was determined by an enzyme immunoassay using commercial reagent kits of Protein Contour LLP (St. Petersburg). Statistical processing of the research results was carried out using parametric and nonparametric statistics using statistical programs Statistica 7.0 for Windows. The mean value (M) and the mean value error (m) were calculated in Microsoft Excel.

Keywords:hemorrhagic fever with renal syndrome, cytokines, children

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