Interactions between hepatitis viruses and lymphoid tissue; modern possibilities of treatment of virus-associated lymphomas
AbstractThe article presents modern data concerning mechanisms of development of virus-induced lymphoproliferation in chronic HCV- and HBV-infections and peculiarities of therapy of cryoglobulinemia, HCV- and HBV-associated lymphomas. The hepatitis viruses C and B are common in the population. Their high immunogenicity promotes the formation of heterogeneous extrahepatic autoimmune hematological disorders during chronic HCV and HBV infections. This may contribute to virus-induced lymphoproliferation and development of non-Hodgkin lymphoma (NHL). The hypothesis of virus-induced mechanism lymphomagenesis lit based on both epidemiological data and the results of successful antiviral therapy, which often contributes to regression of certain types of virus-associated NHL. We analyzed the role of chronic HCV- and HBV virus infection, as well as some other hepatitis viruses in lymphomagenesis. We have demonstrated the effectiveness of antiviral drugs as a new approach to the therapy of virus-associated lymphomas. Modern antiviral therapy can significantly improve the outcomes of HCV- and HBV-associated lymphomas, and in some cases probably to prevent their development.
Keywords:chronic HCV-infection, chronic HBV-infection, extrahepatic manifestation, crioglobulinemia, chronic lymphoproliferative disorders, non-Hodgkin lymphoma
Infectious Diseases: News, Opinions, Training. 2017; (6): 53-61. DOI: 10.24411/2305-3496-2017-00005