Interactions between hepatitis viruses and lymphoid tissue; modern possibilities of treatment of virus-associated lymphomas

• Evgeniy V. Kryukov
• Pop V.P.
• Rukavitsyn O.A.

AbstractThe article presents modern data concerning mechanisms of development of virus-induced lymphoproliferation in chronic HCV- and HBV-infections and peculiarities of therapy of cryoglobulinemia, HCV- and HBV-associated lymphomas. The hepatitis viruses C and B are common in the population. Their high immunogenicity promotes the formation of heterogeneous extrahepatic autoimmune hematological disorders during chronic HCV and HBV infections. This may contribute to virus-induced lymphoproliferation and development of non-Hodgkin lymphoma (NHL). The hypothesis of virus-induced mechanism lymphomagenesis lit based on both epidemiological data and the results of successful antiviral therapy, which often contributes to regres­sion of certain types of virus-associated NHL. We analyzed the role of chronic HCV- and HBV virus infection, as well as some other hepatitis viruses in lymphomagenesis.

We have demonstrated the effectiveness of antiviral drugs as a new approach to the therapy of virus-associated lymphomas. Modern antiviral therapy can significantly improve the outcomes of HCV- and HBV-associated lymphomas, and in some cases probably to prevent their development.

Keywords:chronic HCV-infection, chronic HBV-infection, extrahepatic manifestation, crioglobulinemia, chronic lymphoproliferative disorders, non-Hodgkin lymphoma

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