Interferon discovery and its clinical experience

• L.A. Denisov
• I.V. Sholokhov

Abstract

This review focuses on the discovery history of interferon and its therapeutic use. Interferons were first described 60 years ago as potent antiviraL agents reLated to the body's first Line of defense. This paper presents the domestic and internationaL experience with the use of intranasaL interferon aLpha-2b for the prevention and treatment of acute respiratory viraL infections (ARVI). The anaLysis of Low-dose interferon efficacy in the treatment of these diseases is given. It was found that post-exposure prophyLaxis with the intranasaL interferon provides an effective strategy against ARVI and infLuenza. In recent years new interferon-based medications have been created for the treatment of acute respiratory viraL diseases, viraL eye diseases, skin and mucosaL herpes infections, aLLergies and gynecoLogicaL diseases. Due to the accumuLated knowLedge and experience we can open a new chapter in the further research of interferons' naturaL properties and their use in the treatment of various human diseases.

Keywords:interferon, history, viral infections, interferon standards

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