Role of viral hepatitis in the development of primary liver cancer in Yakutia

• Sleptsova S.S.
• Rakhmanova A.G.
• V.V. Sharoyko

Abstract

Actualite. The Republic of Sakha (Yakutia) is considered as a hyperendemic region of the Russian Federation on the prevalence of hemocontact viral hepatitis B, C and D. The rating and ranking of risk factors for the formation of cirrhosis and primary liver cancer in patients with chronic viral hepatitis B, C and D in the Republic of Sakha (Yakutia) is a serious health care problem.

The purpose of the study. To identify the risk factors for primary liver cancer among people with chronic viral hepatitis in the Republic of Sakha (Yakutia).

Material and methods. The official statistics in the Republic of Sakha (Yakutia), the data of the Yakut republican oncologic dispensary and of viral hepatitis clinic in Yakutsk in the period from 1996 to 2013 were carried out complex clinical, serological and molecular biological research methods to the study of HCV genotype B, C and D.

Results. The high incidence of chronic viral hepatitis B, C and D in the Republic of Sakha (Yakutia) to determine the role of hepatitis viruses in the formation of adverse outcomes such as cirrhosis and primary liver cancer. It proved the impact of the most significant risk factors for the development of cirrhosis and primary liver cancer in chronic viral hepatitis among the indigenous populations living in different geographical areas of the country. Disclosed problem combined effects of risk factors for primary liver cancer in people of indigenous nationality of the Republic of Sakha (Yakutia), predominantly male, living in rural areas, is the simultaneous viral replication of hepatitis B, C and D in people with genetically caused changes in the activity of alcohol dehydrogenase and aldehyde dehydrogenase.

Conclusions. Cartographic isolated regions of Yakutia, the most affected by the virus of hepatitis B, C and D to the progressive course of the disease to cirrhosis and liver cancer. defined The genotype of hepatitis B & D which significantly more likely promoting of primary liver cancer was defined. Also it was noted that the combined mixed-replication of viruses is a risk factor for primary liver cancer.

Keywords:chronic viral hepatitis, cirrhosis, primary liver cancer, alcohol dehydrogenase, aldehyde dehydrogenase

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