Indicators of cystatin C, creatinine and NGAL in patients hemorrhagic fever with renal syndrome

• E.M. Mingazova
• Damir A. Valishin
• Alexander Zh. Gilmanov
• L.R. Shaykhullina

Abstract

Introduction. Acute kidney injury (AKI) is a frequent complication of hemorrhagic fever with renal syndrome (HFRS). The objective evaluation of AKI severity degree is significant in determining the amount of medical actions at HFRS.

Objective. The shifts of AKI biomarkers’ levels (urine NGAL, serum cystatin C and serum creatinine) at different periods of HFRS were evaluated. Methods: Depending to HFRS severity the patients were divided into groups with severe (n=16) and moderate form of HFRS (n=10); the control group included 18 healthy individuals. The levels of biomarkers were measured by ELISA.

Results. The serum concentration of creatinine and cystatin C – markers of glomerular pathology – increased significantly in HFRS, peaking at oligouric period; while changes of cystatin C were more rapid. Urine NGAL level – marker of renal tubular damage – increased 30 to 96 times compared to the control group in fever period of HFRS and gradually decreased thereafter.

Conclusion. The use of modern biochemical markers of renal pathology (sCystatin C, uNGAL) in HFRS, along with traditional indicators, allows a more differentiated approach to the assessment of renal pathology and gives additional evidence to highlight stage and severity of the disease.

Keywords:NGAL, cystatin C, hemorrhagic fever with renal syndrome, acute kidney injury

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