Bolivian hemorrhagic fever

• V.A. Markin
• Vladimir B. Pantyukhov

Abstract

Bolivian hemorrhagic fever is zooanthroponoses, the causative agent of which – Machupo virus – is one of the most virulent arenaviruses for humans. Presumably, the infecting dose for humans is about 10 virions, the most common route of infect transmission is aerosol. Levels of mortality in some effective disease area reach 87,4 %, and morbidity – up to 21 %. Patients with BHF are contagious. Prevention and treatment have not been developed. The above describes the Machupo virus in the event of its introduction to the non-endemic area as the agent that represents a threat to bio-safety, even for highly developed countries. To ensure biological safety of Russia against BHF it is expedient to develop prevention, treatment and diagnosis. The analysis of presented materials can justify the use of laboratory animals, including the modeling of BHF in humans and development of pathogenic approaches for the laboratory evaluation of the effectiveness of vaccines and chemotherapeutic agents.

Keywords:Bolivian hemorrhagic fever, Machupo virus, epidemiology, manifestations in humans, pathogenesis, diagnosis, prevention, treatment

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