Hard-to-treat patient with hepatitis C – what will change with interferon-free therapy?

• Olga O. Znoyko

AbstractThe article explores current and future approaches to the management of hard-to-treat patients with chronic HCV infection. Specific features of hard-totreat patients are reviewed in the context of upcoming implementation of IFN-free regimens. Recently published data resulted from completed IFN-free regimens’ studies is presented and discussed with a special focus on traditionally hard-to-treat populations including patients with: previous virological failures, non-CC IL-28B genotype, high viral load, metabolic disorders, progressed fibrosis or cirrhosis and finally – liver transplant patients.

Keywords:hard-to-treat patients, HCV, treatment, IFN-free regimens

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