Results of highly active antiretroviral therapy (start of therapy at 2005–2008 years)
AbstractThe results of highly active antiretroviral therapy application and the reasons of change of its schemes in HIV-infected patients, which have begun therapy in 2005-2008 in the Samara regional center on preventive maintenance and struggle against AIDS and infectious diseases and continuing it till March, 2011 are described in the article. A study included 77 patients (made 36 men, 41 women), among which were particularly: addicts and consumers of psychoactive substances, patients with sexually transmitted diseases, gomo-and bisexuals, patients with chronic hepatitis C, and with hepatitis C and B at the same time.
The majority of patients show well acceptability of highly active antiretroviral therapy carried out by years.
However there are problems complicating managing such patients, most widespread of which – the late address of patients at the advanced stage of HIV infection for carrying out therapy and non-compliance of patients.
Problem with treatment compliance – one of the major factors defining efficiency of highly active antiretroviral therapy. Strict observance of a mode of therapy is important. In this research therapy was interrupted by 10 patients (6 men, 4 women). After therapy start they noted considerable improvement of a condition in this connection independently interrupted treatment, but further in connection with deterioration of health or in connection with pregnancy came back to therapy.
At the moment of therapy start all patients received three-componential therapy: nucleotide reverse transcriptase inhibitor, non-nucleotide reverse transcriptase inhibitor or protease inhibitors.
The reasons of change of highly active antiretroviral therapy scheme are connected with collateral actions, an inefficiency of carried-out therapy, carrying out antiviral therapy of chronic hepatitis C at the same time with highly active antiretroviral therapy, transfer to the scheme of reception of preparations with less toxic remote undesirable phenomena, temporary lack of necessary preparations.
Keywords:highly active antiretroviral therapy, HIV, treatment compliance, nucleotide reverse transcriptase inhibitors, protease inhibitors