Influence of polymorphic genes on development of an adverse course of flu

• N.O. Bokova
• Nikolay D. Yushchuk
• Kristina R. Dudina
• Olga O. Znoyko
• D.Yu. Trofimov
• Dmitry D. Abramov
• Irina P. Balmasova
• E.I. Kelly

Abstract

The objective. Justification of possibility of forecasting of outcomes of flu on the basis of the genetic analysis of DNA of the person for improvement of tactics of supervision of patients.

Materials and methods. For carrying out genetic research 300 patients, from them 232 patients with the flu caused by various types/subtypes of a virus, and 68 sick acute respiratory disease of other etiology are selected. The group of control (healthy faces) consisted of 207 people which structure on a floor and age corresponded to groups of patients with flu and acute respiratory disease.

Results. 4 polymorphism of genes of the person (G-88T and C-123A of a gene of Mх1, rs12252 of a gene of IFITM3, T-159C of a gene of CD14), having impact on development of the flu caused by different types/subtypes of a virus, and other sharp respiratory diseases, their current and outcomes are revealed. The carriage of genotypes of GT of a gene of Mх1 (G-88T), CA of a gene of Mх1 (C-123A), the CC gene of CD14 (T-159C) at patients with flu A (H1N1) pdm09 creates high risk of development of pneumonia at the medium-weight course of a disease, promotes increase of risk of a heavy course of flu with high probability of a lethal outcome. The carriage of a genotype of CT rs12252 of a gene of IFITM3 increases risk of development of flu, as a whole, and a genotype of CA of a gene of Mх1 (C-123A) – risk of the complicated course of flu A (H3N2).

Keywords:flu A (H1N1) pdm09, flu A (H3N2), flu B, acute respiratory disease, genetic polymorphism, antiviral protein, interleukin, cellular receptor, interferon, SNP genotyping

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