Clinical case of combined course of focal pulmonary tuberculosis with secondary amyloidosis and COVID-19

• Olga V. Alpidovskaya

Abstract

The article presents a clinical description of a case of acute respiratory distress syndrome development and the disintegration of the focal pulmonary tuberculosis capsule against the background of COVID-19 with a fatal outcome.

The peculiarity of the case is a rare localization of pulmonary tuberculosis (S_VIII–IX), which lasted for several years. An autopsy in the lower parts of the lungs revealed a disintegrated capsule with signs of tuberculous granulomatous inflammation, caseous foci with exudative-productive inflammation along the periphery of the necrotic focus, amyloid deposition with areas of sclerosis was detected in the lung vessels.

Keywords:COVID-19; pneumonia; fibro-focal tuberculosis; amyloidosis of pulmonary vessels

References

1. Temporary guidelines for the provision of anti-tuberculosis care in the context of a pandemic of a new coronavirus infection (COVID-19) All-Russian public organization «Russian Society of Phthisiologists». Moscow, 2020: 48 p. (in Russian)

2. Tuberculosis in adults: clinical recommendations. All-Russian public organization «Russian Society of Phthisiologists». Moscow, 2020: 121 p. (in Russian)

3. Shishkin A.N., Krokhaleva L.L., Fadina Zh.V., Potepun T.B., Azanchevskaya S.V. Features of the course of amyloidosis in patients with pulmonary tuberculosis. Nefrologiya [Nephrology]. 2003; 7 (2): 46–9. URL: https://cyberleninka.ru/article/n/osobennosti-techeniya-amiloidoza-u-bolnyh-tuberkulezom-legkih (date of access 12 August 2023). (in Russian)

4. Gomzikova E.A., Samsonova M.V., Chernyaev A.L. Pulmonary amyloidosis: basics of diagnostics. Prakticheskaya pul’monologiya [Practical Pulmonology]. 2017; (3): 90–7. URL: https://cyberleninka.ru/article/n/amyloidoz-legkih-osnovy-diagnostiki (in Russian)

5. Vorob’eva O.V., Lastochkin A.V., Gimaldinova N.E. Clinical and morphological characteristic case of system al-amyloidosis. Sovremennye problemy nauki i obrazovaniya [Modern Problems of Science and Education]. 2020; (3): 151. DOI: https://doi.org/10.17513/spno.29795 (in Russian)

6. Vorob’eva O.V., Lastochkin A.V., Romanova L.P. Changes in organs in COVID-19 at chronic obstructive disease and pulmonary tuberculosis. A clinical case. Profilakticheskaya meditsina [Preventive Medicine]. 2021; 24 (5): 41–4. DOI: https://doi.org/10.17116/profmed20212405141 (in Russian)

7. Vorob’eva O.V. Morphological changes in organs after infection with SARS-CoV-2 against the background of AL-amyloidosis. Profilakticheskaya meditsina [Preventive Medicine]. 2021; 24 (12): 79–83. DOI: https://doi.org/10.17116/profmed20212412179 (in Russian)

8. Xu B., Fan C.Y., Wang A.L., Zou Y.L., Yu Y.H., He C., et al. Suppressed T cell-mediated immunity in patients with COVID-19: a clinical retrospective study in Wuhan, China. J Infect. 2020; 81 (1): e51–60. DOI: https://doi.org/10.1016/j. jinf.2020.04.012

9. Todorov S.S., Deribas V.Yu., Kaz’min A.S., et al. Pathomorphological changes in pulmonary vessels at different terms of lethal outcomes of patients with COVID-19. Meditsinskiy vestnik Yuga Rossii [Medical Bulletin of the South of Russia]. 2021; 12 (2): 54–61. DOI: https://doi.org/10.21886/2219-8075-2021-12-2-54-61 (in Russian)

All articles in our journal are distributed under the Creative Commons Attribution 4.0 International License (CC BY 4.0 license)