Prospects of hematopoietic stem cell transplantation for patients with HIV infection
AbstractAt the same time, for about 28% of the causes of deaths in patients with human immunodeficiency virus (HIV) infection are malignant neoplasm, including lymphomas. The hematopoietic stem cell transplantation (HSCT) is one of the main approaches in the treatment of lymphoproliferative diseases (LPDs).
The aim of this study is to conduct a systematic analysis of data and to identify existing approaches and prospects for HSCT in patients with HIV infection.
Material and methods. A systematic review of 66 articles, including 62 from foreign sources, was conducted for the period between 2009 and 2023. The search was conducted using the PubMed, Web of Science, Scopus, and eLibrary databases, as well as Google Scholar.
Results and discussion. HSCT is an indispensable component of the treatment for LPDs in HIV patients, as well as a possible method for eliminating one of the HIV-1 reservoir and controlling viral load. To minimize the risk of re-infection with hematopoietic stem cells (HSCs), it is recommended to use cells carrying the 32-base pair deletion C-C chemokine receptor type 5 (CCR5Δ32/Δ32) mutation. Given the high specificity and potential for wide application, the clustered regularly interspaced short palindromic repeats / CRISPR-associated protein 9 (CRISPR/Cas-9) system seems to be a promising method for editing the HSCs genome.
Conclusion. HSCT in HIV-positive patients is an essential component of LPDs treatment, and can also be considered as a potential means of achieving stable and long-term remission from HIV infection. Further research is needed to fully understand the potential benefits and risks of this approach.
Keywords: HIV-infection; hematopoietic stem cell transplantation; lymphoproliferative diseases; CRISPR/Сas9; ZFN; TALEN
Funding. There is no funding to report.
Conflict of interest. The authors declare no conflict of interest.
Contribution. Article writing, article design, article editing – Gadzhikulieva M.M.; article writing, article design – Chernysheva O.O.; article design, article editing – Tsyganova E.V., Dudina G.A.
For citation: Gadzhikulieva M.M., Chernysheva O.O., Tsyganova E.V., Dudina G.A. Prospects of hematopoietic stem cell transplantation for patients with HIV infection. Infektsionnye bolezni: novosti, mneniya, obuchenie [Infectious Diseases: News, Opinions, Training]. 2024; 13 (2): 74–85. DOI: https://doi.org/10.33029/2305-3496-2024-13-2-74-85 (in Russian)
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