Complex approach to the treatment of patients with herpetic infection in the maxillofacial region
AbstractObjective – to assess the effectiveness of the original combined medicine Herpferon® (ointment for topical and external use) in the complex therapy of chronic recurrent herpetic stomatitis and dermatitis of the maxillofacial region.
Material and methods. A simple prospective clinical study was conducted, which included 60 patients (aged 18 to 45 years) with chronic recurrent herpetic stomatitis and mild maxillofacial dermatitis. All patients received basic therapy – acyclovir orally and antiseptic treatment of sores. Additionally, from the 5th day of the disease exacerbation a keratoplastic agent (vitamin A oil solution) was applied to the oral mucosa until complete epithelization of the affected areas.
Patients were divided into 2 groups: the first group patients (observation group, n=30) in addition to the basic therapy received the combined medicine Herpferon® (interferon alpha-2b + acyclovir + lidocaine) applied topically to the sores 5 times a day with a 4-hour interval for 5 days. The second group patients (comparison group, n=30) received only basic therapy (without Herpferon®).
The following main clinical research methods were used: a patient survey, medical check-up by a dentist and dermatology and venereology specialist, as well as additional examination: general blood analysis, tests by molecular biological methods aimed at detecting specific DNA fragments of HSV type 1–2 (PCR, real-time PCR).
During treatment the effectiveness of the given medicine, the presence and severity of side effects were assessed.
Statistical processing of the research results was performed using descriptive statistics computer software for Windows XP. The mean, standard deviation, standard error of the mean and reliability of the mean differences were calculated. Differences were considered statistically significant at p<0.05.
Results and discussion. The prescribed antiviral treatment with the use of the combined medicine Herpferon® applied topically to the affected areas of skin and mucous membranes resulted in a rapid relief of the pain syndrome and resolution of the pathological herpetic process in the maxillofacial region (on the vermilion border of the lips, oral mucosa and facial skin).
Conclusion. The use of the combined medicine Herpferon® in the complex treatment of patients with chronic recurrent herpetic stomatitis and mild dermatitis of the maxillofacial region showed its high effectiveness, faster resolution of the pathological process, good tolerability, no side effects and in overall improved patients’ quality of life.
Keywords: oral mucosa; herpetic infection; maxillofacial region; interferon alpha; ointment; Herpferon®
Funding. The study had no sponsor support.
Conflict of interest. The authors declare no conflict of interest.
Contribution. Conducting research, formulating and developing key goals and objectives, participating in scientific design, preparing work, editing text – Yunusova E.I.; conducting research, developing a concept, participating in scientific design, preparing the text, editing the text – Silantieva E.N.; conducting research, participating in scientific design, preparing the text – Ruvinskaya G.R.; conducting research, preparing the text, editing the text – Zalyaleeva S.A.
For citation: Yunusova E.I., Silantieva E.N., Ruvinskaya G.R., Zalyaleeva S.A. Complex approach to the treatment of patients with herpetic infection in the maxillofacial region. Infektsionnye bolezni: novosti, mneniya, obuchenie [Infectious Diseases: News, Opinions, Training]. 2024; 13 (2): 37-44. DOI: https://doi.org/10.33029/2305-3496-2024-13-2-37-44 (in Russian)
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