Antiherpesvirus activity of nanocapsulated aminooxide – based derivatives of biguanidine – innovative biotechnological medical drags with fundamentally new mechanism of antiinfectogenic action

• Nikolai D. Lvov
• Elena M. Panyukova

Abstract

The article presents the results of studying the antiherpesvirus activity of innovative biotechnological medical preparations with fundamentally new mechanism of antiinfectogenic action – nanocapsulated aminooxide – based derivatives of biguanidine. We assessed the effect of the drug lyotropic liquid crystal of chlorhexidine base on the reproduction of the herpesviruses 2 in the in vitro. A pronounced inhibitory effect of the drug was detected. The Chemotherapeutic Index was 10.0.

Keywords: Herpesvirus; innovative biotechnological nanocapsulated drugs; studying of the inhibitory effect in the sensitive cells (in vitro)

References

1. Farkas E., Kiss D., Zelkó R. Study on the release of chlorhexidine base and salts from different liquid crystalline structures. Int J Pharm. 2007; 340 (1–2): 71-5. DOI: https://doi.org/10.1016/j.ijpharm.2007.03.038 PMID: 17467206.

2. L’vov N.D., Panyukova E.M., Nikitina A.A. Modern methods of rapid diagnosis of herpes virus infection of different localization. Clinico-virological parallels. Educational edition. In: New and Recurring Viral Infections in the Biosafety System of the Russian Federation. Moscow, 2014. 129–37. (in Russian)

3. L’vov N.D. Herpesviruses – an underestimated threat to humanity. In: NRCEM Polyclinic No. 1 General Management Department of the President of Russian Federation. VII Scientific-Practical Conference with International Participation. «Immune System Health. Immunotropic Infection. New Tumor Markers». Moscow, March 16, 2018: 49–58. (in Russian)

4. Lvov N.D. Human herpesviruses – systemic, integrative immunopathology. RMZh [Russian Medical Journal]. 2012; (22): 1133–7. (in Russian)

5. Ershov F.I., Romantsov M.G. Medical drugs, used for the treatment of viral diseases. Manual for physicians. Moscow: GEOTAR-Media, 2007. (in Russian)

6. Samad A., Sultana Y., Aqil M. Liposomal drug delivery systems: an update review. Curr Drug Deliv. 2007; 4 (4): 297–305. DOI: https://doi.org/10.2174/156720107782151269 PMID: 17979650.

7. L’vov N.D. Herpesvirus infections. General characteristics. Monograph. Chapter 2.3.3.1. Viral infections of the skin and mucous membranes. In: D.K. L’vov (ed.). Guide to Virology: «Viruses and Viral Infections of the Human». Moscow. Meditsinskoe informatsionnoe agentstvo, 2013: 599–603. (in Russian)

8. De Bolle L., Naesens L., De Clercq E. Update on human herpesvirus 6 biology, clinical features, and therapy. Clin Microbiol Rev. 2005; 18 (1): 217–45. DOI: https://doi.org/10.1128/CMR.18.1.217-245.2005 PMID: 15653828; PMCID: PMC544175.

9. Mironov A.N., Bunatian N.D., Vasil’ev A.N., et al. Guidelines for conducting preclinical trials of drugs. Pt 1. Moscow: Grif i K, 2012: 944 p. (in Russian)

10. Nozdrachov A.D., Mar’yanovich A.T., Polyakov E.L., Sibarov A.D., Khavinson V.H. Nobel Prizes in Physiology or Medicine for 100 years. Saint Petersburg: Gumanistika, 2002. 688 p. (in Russian)

11. Pavlova I.B., Kononenko A.B., Tolmacheva G.S., Rytsarev A.Yu. The formation of biofilms by pathogenic bacteria and the effect of a new disinfectant on them. Problemy veterinarnoy sanitarii, gigieny i ekologii [Problems of Veterinary Sanitation, Hygiene and Ecology]. 2018; (4): 56–62. (in Russian)

All articles in our journal are distributed under the Creative Commons Attribution 4.0 International License (CC BY 4.0 license)