Clinical and immunological aspects of chronic tick-borne borreliosis

Abstract

Clinical manifestations and changes in the immune status in patients with a chronic course of tick-borne borreliosis in the Krasnoyarsk Territory were studied. Chronization of the infectious process after the erythema form of the disease was observed in 7.8% of patients, after the non-erythema form - in 37.5% of patients, after mixed infection with tick-borne encephalitis - in 33.2% of patients; newly diagnosed chronic borreliosis was diagnosed in 21.5% of patients. The disease was characterized by a relapsing course (88.8%), damage to the musculoskeletal system (42.9%), nervous system (34.1%) and a combination of organ lesions (23.0%). Long-term elevated indicators of the acute phase of inflammation, α1- and α2-globulins, and deficiency of γ-globulins were observed. The immune status was characterized by cellular immunodeficiency with a decrease in the cytotoxic mechanisms of immune defense and a defect in the macrophage-phagocytic link of the immune system. Changes in the humoral immunity link were consistent with the increasing activity of the infectious process.

Keywords:tick-borne borreliosis, chronic course, immune status

Conflict of interests. Authors declare no conflict of interest

Funding. The study had no sponsor support.

Contribution. Concept and design of the study - Minoranskaya N.S., Tikhonova E.P.; collection and processing of material -Chernykh V.I., Tyushevskaya O.A.; statistical processing of results - Chernykh V.I.; text writing - Minoranskaya N.S.; editing -Tikhonova E.P.

For citation: Minoranskaya N.S., Chernykh V.I., Tikhonova E.P., Tyushevskaya O.A. Clinical and immunological aspects of chronic tick-borne borreliosis. Infektsionnye bolezni: novosti, mneniya, obuchenie [Infectious Diseases: News, Opinions, Training]. 2020; 9 (3): 61-6. DOI: https://doi.org/10.33029/2305-3496-2020-9-3-61-66 (in Russian)

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CHIEF EDITOR
Aleksandr V. Gorelov
Academician of the Russian Academy of Sciences, MD, Head of Infection Diseases and Epidemiology Department of the Scientific and Educational Institute of Clinical Medicine named after N.A. Semashko ofRussian University of Medicine, Ministry of Health of the Russian Federation, Professor of the Department of Childhood Diseases, Clinical Institute of Children's Health named after N.F. Filatov, Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, Deputy Director for Research, Central Research Institute of Epidemiology, Rospotrebnadzor (Moscow, Russian Federation)

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