Clinical and immunological aspects of chronic tick-borne borreliosis
AbstractClinical manifestations and changes in the immune status in patients with a chronic course of tick-borne borreliosis in the Krasnoyarsk Territory were studied. Chronization of the infectious process after the erythema form of the disease was observed in 7.8% of patients, after the non-erythema form - in 37.5% of patients, after mixed infection with tick-borne encephalitis - in 33.2% of patients; newly diagnosed chronic borreliosis was diagnosed in 21.5% of patients. The disease was characterized by a relapsing course (88.8%), damage to the musculoskeletal system (42.9%), nervous system (34.1%) and a combination of organ lesions (23.0%). Long-term elevated indicators of the acute phase of inflammation, α1- and α2-globulins, and deficiency of γ-globulins were observed. The immune status was characterized by cellular immunodeficiency with a decrease in the cytotoxic mechanisms of immune defense and a defect in the macrophage-phagocytic link of the immune system. Changes in the humoral immunity link were consistent with the increasing activity of the infectious process.
Keywords:tick-borne borreliosis, chronic course, immune status
Conflict of interests. Authors declare no conflict of interest
Funding. The study had no sponsor support.
Contribution. Concept and design of the study - Minoranskaya N.S., Tikhonova E.P.; collection and processing of material -Chernykh V.I., Tyushevskaya O.A.; statistical processing of results - Chernykh V.I.; text writing - Minoranskaya N.S.; editing -Tikhonova E.P.
For citation: Minoranskaya N.S., Chernykh V.I., Tikhonova E.P., Tyushevskaya O.A. Clinical and immunological aspects of chronic tick-borne borreliosis. Infektsionnye bolezni: novosti, mneniya, obuchenie [Infectious Diseases: News, Opinions, Training]. 2020; 9 (3): 61-6. DOI: https://doi.org/10.33029/2305-3496-2020-9-3-61-66 (in Russian)
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