Alopecia areata as a clinical manifestation of autoimmune inflammation due to vitamin D deficiency

AbstractVitamin D (D-hormone) deficiency is a new noncommunicable pandemic of the 21st century. The article presents new data on the role of vitamin D as one of the regulators of immune responses in the mechanism of development of autoimmune diseases. Using one of the autoimmune pathologies as alopecia areata (HA), an analysis was made of the relationship between the immune and hormonal regulation of the hair follicle and the role of vitamin D in the pathogenesis of this autoimmune disease. The appearance of any autoimmune disease, including GA, can be conditionally considered as one of the symptoms of a long-existing vitamin D deficiency. Normalization of vitamin D levels and hormonal levels can be considered as a pathogenetic approach to the treatment of GA and the prevention of other autoimmune pathologies.

Keywords:vitamin D deficiency, autoimmune diseases, alopecia areata, glucocorticosteroid hormones

Funding. The study had no sponsor support.

Conflict of interests. The authors declare no conflict of interests.

For citation: Kalinchenko S.Yu., Vorslov L.O., Terushkin R.A. Alopecia areata as a clinical manifestation of autoimmune inflammation due to vitamin D deficiency. Infektsionnye bolezni: novosti, mneniya, obuchenie [Infectious Diseases: News, Opinions, Training]. 2020; 9 (2): 99-105. DOI: 10.33029/2305-3496-2020-9-2-99-105 (in Russian)

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CHIEF EDITOR
Aleksandr V. Gorelov
Academician of the Russian Academy of Sciences, MD, Head of Infection Diseases and Epidemiology Department of the Scientific and Educational Institute of Clinical Medicine named after N.A. Semashko ofRussian University of Medicine, Ministry of Health of the Russian Federation, Professor of the Department of Childhood Diseases, Clinical Institute of Children's Health named after N.F. Filatov, Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, Deputy Director for Research, Central Research Institute of Epidemiology, Rospotrebnadzor (Moscow, Russian Federation)

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