Immunostructure of the population of the city of Yakutsk to hepatitis A virus

Abstract

The aim of this study was to establish the level of seropositivity to the hepatitis A virus (HA) among different age groups of the population of Yakutsk.

Material and methods. The materials of the official statistics in the Republic of Sakha (Yakutia) are used in the work. Blood serums were selected by random sampling from 1018 people aged 0 to 70 years who were treated in medical institutions in Yakutsk. IgG class antibodies to the HA virus were determined by the ELISA method (a test system for the qualitative determination of antibodies to the HA virus with a sensitivity of at least 20 IU/l).

Results and discussion. A decrease in the incidence of HA on the background of vaccination was revealed. Analysis of the dynamics of the level of morbidity and vaccination of the population revealed an inverse correlation of average strength (Pearson's corellation coefficient r=-0.67; p=0.003).

Keywords:viral hepatitis A, vaccination, seropositivity

Funding. The study had no sponsor support.

Conflict of interests. The authors declare no conflict of interests.

For citation: Semenova V.K., Sleptsova S.S., Ignatyeva, M.E., Malinnikova E.Yu. Immunostructure of the population of the city of Yakutsk to hepatitis A virus. Infektsionnye bolezni: novosti, mneniya, obuchenie [Infectious Diseases: News, Opinions, Training]. 2020; 9 (2): 84-8. DOI: 10.33029/2305-3496-2020-9-2-84-88 (in Russian)

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CHIEF EDITOR
Aleksandr V. Gorelov
Academician of the Russian Academy of Sciences, MD, Head of Infection Diseases and Epidemiology Department of the Scientific and Educational Institute of Clinical Medicine named after N.A. Semashko ofRussian University of Medicine, Ministry of Health of the Russian Federation, Professor of the Department of Childhood Diseases, Clinical Institute of Children's Health named after N.F. Filatov, Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, Deputy Director for Research, Central Research Institute of Epidemiology, Rospotrebnadzor (Moscow, Russian Federation)

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