Antibacterial therapy of lysterious lesions of the central nervous system in real clinical practice

Abstract

Listeria meningitis is a relatively rare disease. Over the past 3 years, Moscow has seen an increase in the number of reported cases of listeriosis from 16 in 2016 to 32 in 2018. Sick mostly adults. A retrospective analysis of etiotropic therapy of 51 patients with Listeria infection with Central nervous system lesions who were on in patient treatment from 2000 to 2019. He showed that empirical antibacterial therapy in the early stages of the disease was often performed using cephalosporins of the third generation, to which L. monocytogenes is resistant. Other drugs with proven clinical efficacy (ampicillin, vancomycin, meropenem) were used at a later date, in cases of prolonged course of the disease. Rehabilitation of the cerebrospinal fluid with a favorable course occurred on the 15th-20th day of the disease. The mortality rate was 25.5%.

Keywords:Listeriosis infection, Lesions of the central nervous system, L. monocytogenes, sensitivity to antibacterial drugs, antibiotic therapy

Funding. The study had no sponsor support.

Conflict of interests. The authors declare no conflict of interests.

For citation: Shishov A.S., Klimova E.A., Karetkina G.N., Ishmukhametov A.A., Solovieva L.Ya., Volkov K.S., Lyapeykova E.A., Chemeris O.Yu., Smetanina S.V., Yushchuk N.D. Antibacterial therapy of lysterious lesions of the central nervous system in real clinical practice. Infektsionnye bolezni: novosti, mneniya, obuchenie [Infectious Diseases: News, Opinions, Training]. 2020; 9 (2): 77-83. DOI: 10.33029/2305-3496-2020-9-2-77-83 (in Russian)

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CHIEF EDITOR
Aleksandr V. Gorelov
Academician of the Russian Academy of Sciences, MD, Head of Infection Diseases and Epidemiology Department of the Scientific and Educational Institute of Clinical Medicine named after N.A. Semashko ofRussian University of Medicine, Ministry of Health of the Russian Federation, Professor of the Department of Childhood Diseases, Clinical Institute of Children's Health named after N.F. Filatov, Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, Deputy Director for Research, Central Research Institute of Epidemiology, Rospotrebnadzor (Moscow, Russian Federation)

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