Development of anatoxin preparations and solution problems of their production in the USSR (material for the preparation of the lecture)

Abstract

The article describes the history of the creation of highly purified concentrated toxoids against anaerobic infections using meatless nutrient media based on modern industrial (in fermenters) technologies.

Keywords:botulinum and tetanus toxoids, meatless nutrient media, industrial (in fermenters) technology

Funding. The study had no sponsor support.

Conflict of interests. The author declare no conflict of interests.

For citation: Lukin E.P. Development of anatoxin preparations and solution problems of their production in the USSR (material for the preparation of the lecture). Infektsionnye bolezni: novosti, mneniya, obuchenie [Infectious Diseases: News, Opinions, Training]. 2020; 9 (1): 116-20. doi: 10.33029/2305-3496-2020-9-1-116-120 (in Russian)

References

1. Burgasov P.N. I had been believing. 3rd ed. Moscow: GEOTAR-Med, 2004: 272 p. (in Russian)

2. Vorobyov A.A. Don’t sum up! Scientifi c writings. Moscow: MIA, 2003: 415 p. (in Russian)

3. Lukin E.P. The creation of a barrier against infections. In: «Worthy to be known». 50 years of the USSR Defense Ministry Virological Center. Comp.: R.N. Lukina, E.P. Lukin, V.K. Bulavko. Sergiev Posad: Ves’ Sergiev Posad, 2004: 146–51. (in Russian)

4. Matveev K.I. Epidemiology and prophylaxis of tetanus. Moscow: Meditsina, 1960: 338 p. (in Russian).

5. Matveev K.I., Schekochikhina E.A., Soykina T.S., et al. Preparation of tetanus toxins and anatoxins in the non-meat media. In: Anaerobic Infections. Proceedings of Inter-Institutional Scientifi c Conference. Moscow, 1960; (9): 88–100. (in Russian)

6. Lebedinsky V.A., Abdulin T.T., Evstigneev V.I., Garin N.S., Lukin E.P. Contribution of the Microbiology Research Institute of the USSR Ministry of Defense in the development of infectious disease problems. Voennomeditsinskiy zhurnal [Military аnd Medical Journal]. 1989; (8): 67–71. (in Russian)

7. We have defended Russia. In: V.N. Orlov (ed.). Moscow, 2000: 205–8. (in Russian)

8. Kravchenko A.T., Shishulina L.M. Distribution of botulism and tetanus causative agents in the USSR. Moscow: Meditsina, 1970: 190 p. (in Russian).

9. Koroleva G.L., Matveev K.I., Volkova Z.M. Preparation of bi- and polyvalent anti-botulinum sera of types A, B, C and E in horses. Zhurnal mikrobiologii, epidemiologii i immunobiologii [Journal of Microbiology, Epidemiology and Immunobiology]. 1958; (5): 83–7. (in Russian)

10. Markin A.P., Lukin E.P., Voronyov A.A., Petrova E.K. The study of botulinum anatoxins. Communication 3. Botulinum anatoxin of type C. Zhurnal mikrobiologii, epidemiologii i immunobiologii [Journal of Microbiology, Epidemiology and Immunobiology]. 1961; (12): 96–9. (in Russian)

12. Kravchenko A.T., Rezepov F.F. To the question of the mechanism of action of antitoxic sera. In: Abstracts of Inter-Institutional Scientifi c Conference, 9–12.04.1957. the USSR Ministry of Health. Moscow, 1957: 43–4. (in Russian)

13. Ashmarin I.P., Vorontsov I.V., Enichev V.M., Lukin E.P. Isolation, purification and some properties of B type Cl. botulinum proteinase. Biokhimiya [Biochemistry]. 1962; 27 (5): 788–93. (in Russian)

14. Rezepov F.F. Standardization principles of purified adsorbed anatoxins. Scientific basis for the production of vaccines and sera. In: Proceedings of the 2nd Inter-Institutional Scientific Conference in Memory of I.I. Mechnikov. Moscow, 1964: 19. (in Russian)

15. Tatochenko V.K. Russian National Calendar of Vaccinations. Immunoprophylaxis-2005: Handbook. 5th ed. Moscow, 2005: 192 p. (in Russian)

16. Infectious diseases in Russia. Statistical reference book. Moscow: Federal’niy tsentr gossanepidnadzora MZ RF, 2002: 69 p. (in Russian)

17. Infectious diseases in the subjects of the Russian Federation for 2016. Moscow, 2017. URL: https://rospotrebnadzor.ru/files/ф%201_рост-сниж_свод%20по%20РФ_январь-декабрь_2018xls (in Russian)

18. Infectious diseases in the subjects of the Russian Federation for 2018. Moscow, 2019. URL: https://rospotrebnadzor.ru/files/ф%201_рост-сниж_свод%20по%20РФ_январь-декабрь_2018xls (in Russian)

All articles in our journal are distributed under the Creative Commons Attribution 4.0 International License (CC BY 4.0 license)

CHIEF EDITOR
Aleksandr V. Gorelov
Academician of the Russian Academy of Sciences, MD, Head of Infection Diseases and Epidemiology Department of the Scientific and Educational Institute of Clinical Medicine named after N.A. Semashko ofRussian University of Medicine, Ministry of Health of the Russian Federation, Professor of the Department of Childhood Diseases, Clinical Institute of Children's Health named after N.F. Filatov, Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, Deputy Director for Research, Central Research Institute of Epidemiology, Rospotrebnadzor (Moscow, Russian Federation)

Journals of «GEOTAR-Media»